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Selectins

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Cell adhesion is an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain, which...

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Related Experiment Video

Updated: Jul 19, 2026

Isolation and Culture Expansion of Tumor-specific Endothelial Cells

Isolation and Culture Expansion of Tumor-specific Endothelial Cells

Published on: October 14, 2015

Endothelial cells and cancer.

L Nikitenko¹, C Boshoff

¹CR U.K. Viral Oncology Group, Wolfson Institute for Biomedical Research, UCL, London WC1E 6BT, UK. l.nikitenko@ucl.ac.uk

Handbook of Experimental Pharmacology

|September 27, 2006

Summary

Endothelial cells are crucial for blood vessel formation and function. Understanding their role in cancer, including endothelial progenitor cells (EPCs), offers new therapeutic strategies for tumor angiogenesis.

Area of Science:

Vascular Biology
Oncology
Cellular Biology

Background:

Endothelial cells are vital for blood and lymph vessel development and function.
Dysregulated endothelial cell proliferation causes pathological angiogenesis and vascular malfunctions, characteristic of cancers.
Circulating endothelial progenitor cells (EPCs) are increasingly recognized for their significant role in these pathological processes.

Purpose of the Study:

To investigate the molecular mechanisms governing EPC mobilization from bone marrow.
To understand EPC homing and differentiation into functional endothelium at neovascularization sites.
To explore the impact of viral oncogenes on endothelial cell plasticity and lifespan in tumorigenesis.

Main Methods:

Analysis of molecular mechanisms regulating endothelial cell behavior.

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Last Updated: Jul 19, 2026

Isolation and Culture Expansion of Tumor-specific Endothelial Cells

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Published on: October 14, 2015

Isolation of Human Endothelial Cells from Normal Colon and Colorectal Carcinoma - An Improved Protocol

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In vitro Method to Observe E-selectin-mediated Interactions Between Prostate Circulating Tumor Cells Derived From Patients and Human Endothelial Cells

In vitro Method to Observe E-selectin-mediated Interactions Between Prostate Circulating Tumor Cells Derived From Patients and Human Endothelial Cells

Published on: May 15, 2014

Studies on endothelial progenitor cell (EPC) mobilization, homing, and differentiation.

Investigation of viral oncogene functions in endothelial cells.

Main Results:

Significant progress in identifying key molecules involved in tumor angiogenesis.
Advancements in targeting tumor angiogenesis for therapeutic interventions.
Ongoing research into the origin and function of endothelium within various tumors.

Conclusions:

Integrated understanding of endothelial cell regulation in tumorigenesis is driving novel cancer treatment approaches.
Targeting endothelial cell properties and functions presents promising therapeutic avenues.
Deciphering EPC behavior and oncogene influence offers potential for innovative cancer therapies.