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Updated: Jul 19, 2026
Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
Morphology control of polylactide microspheres enclosing irinotecan hydrochloride with polylactide based polymer
Satoru Nishino1, Akio Kishida, Hidekazu Yoshizawa
1Department of Chemical Engineering, Nara National College of Technology, 22 Yata, Yamatokoriyama, Nara 639-1080, Japan.
Abstract:
We introduced newly biodegradable polymer surfactant to poly(D,L-lactide) microspheres for exhibiting precisely controlled release rate of antitumor agent. We newly designed biodegradable polymer surfactant, poly(ethyleneoxide monooleate)-block-poly(D,L-lactide); (MOPEO-PLA), which has a biocompatible, oil-soluble and compatible with polylactide matrices. Polylactide (PLA) microspheres with MOPEO-PLA enclosing Irinotecan hydrochloride (CPT-11) was successfully fabricated by solvent evaporation method via O/O emulsion. The surface morphology was strongly affected to MOPEO-PLA content in PLA microspheres; the wrinkles on microsphere surface were decreased with increasing MOPEO-PLA content. It was found from DSC scans that Tg of PLA drastically decreased with introducing MOPEO-PLA, indicating that MOPEO-PLA miscible with PLA. MOPEO-PLA, played as a plasticizer, made the surface smoothed. The rate of release in a short duration was minimum value at adding 20 wt.% of MOPEO-PLA. This result was due to the smaller surface area of PLA microspheres with smoothed surface.
