Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Exposure to multiple environmental agents and their effect.

Janna G Koppe1, Alena Bartonova, Gabriele Bolte

  • 1Ecobaby Foundation and Emma Children's Hospital Academic Medical Centre University of Amsterdam, The Netherlands. Janna.Koppe@inter.nl.net

Acta Paediatrica (Oslo, Norway : 1992). Supplement
|September 27, 2006
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Study protocol for evaluating integrated urban development plans: impacts on health, social equity, and environmental sustainability in Germany.

BMC public health·2026
Same author

Intersectional inequalities in self-rated health in Germany across sex/gender, migration, education and income: a cross-sectional study.

Journal of epidemiology and community health·2026
Same author

Efficacy and safety of eptinezumab in adults with chronic migraine and medication-overuse headache who also received patient education: 24-week results of the randomized RESOLUTION trial.

The journal of headache and pain·2026
Same author

Benefits of eptinezumab on patient-reported disease burden and health-related quality of life in adults with chronic migraine and medication-overuse headache: Results from the placebo-controlled RESOLUTION trial.

Cephalalgia : an international journal of headache·2026
Same author

Brief intervention for inappropriate z-hypnotics use in older adults: a before and after intervention study in primary care.

Scandinavian journal of primary health care·2026
Same author

Dominant clones leverage developmental epigenomic states to drive ependymoma.

Nature·2026
Same journal

Policy and science in children's health and environment: recommendations from the PINCHE project.

Acta paediatrica (Oslo, Norway : 1992). Supplement·2006
Same journal

Air pollution: a threat to the health of our children.

Acta paediatrica (Oslo, Norway : 1992). Supplement·2006
Same journal

Environmental tobacco smoke exposure and children's health.

Acta paediatrica (Oslo, Norway : 1992). Supplement·2006
Same journal

Ionizing radiation and children's health: conclusions.

Acta paediatrica (Oslo, Norway : 1992). Supplement·2006
Same journal

Adverse health effects of children's exposure to pesticides: what do we really know and what can be done about it.

Acta paediatrica (Oslo, Norway : 1992). Supplement·2006
Same journal

Children's exposure to polybrominated diphenyl ethers.

Acta paediatrica (Oslo, Norway : 1992). Supplement·2006
See all related articles
This summary is machine-generated.

Children face numerous environmental exposures, necessitating a shift from single-chemical toxicology to assessing cumulative risks from multiple stressors. Enhanced regulation and a precautionary approach are crucial for protecting child health.

Area of Science:

  • Environmental Health
  • Toxicology
  • Pediatrics

Background:

  • Children are susceptible to adverse health effects from multiple physical, chemical, and biological exposures.
  • Classical toxicology's single-chemical approach is insufficient for assessing the risks of combined environmental stressors.

Purpose of the Study:

  • To explore methods for assessing risks from multiple environmental stressors.
  • To investigate the extent of synergistic risks and potential for prevention through regulation.

Main Methods:

  • Examining studies on mixtures (e.g., smoking, air pollution) without isolating individual agents.
  • Investigating individual substances and their interactions within the context of dose to the receptor.

Main Results:

Related Experiment Videos

  • Mixtures can cause effects, but single-agent causation is often unclear.
  • Cumulative low-dose exposures can be more toxic than single high doses, exemplified by endocrine disruption.
  • Interactions between chemicals, heavy metals, and concurrent diseases must be considered.

Conclusions:

  • Defining and studying groups of multiple stressors is essential, aligning with frameworks like the US EPA's Cumulative Risk Assessment.
  • Increased precaution is needed for regulating multiple stressors on young children due to their heightened sensitivity.
  • A community-based approach involving diverse stakeholders is necessary to resolve regulatory conflicts.