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Related Experiment Videos

Modeling ischemia-induced dyssynchronous myocardial contraction.

David P Strum1, Michael R Pinsky

  • 1Cardiopulmonary Research Laboratory, Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15261, USA.

Anesthesia and Analgesia
|September 27, 2006
PubMed
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Quantifying left ventricular (LV) dyssynchrony is challenging. A sine wave model and phase angle analysis effectively detect and quantify regional dyssynchrony during ischemia, similar to esmolol-induced effects.

Area of Science:

  • Cardiology
  • Biomedical Engineering
  • Physiology

Background:

  • Left ventricular (LV) contraction dyssynchrony is difficult to quantify.
  • Previous models used esmolol-induced dyskinesis to assess LV dyssynchrony.
  • The current study investigates assessing dyssynchrony during regional ischemia.

Purpose of the Study:

  • To test if a sine wave model and phase angle analysis can assess contraction dyssynchrony during regional ischemia.
  • To compare the effects of intracoronary esmolol and matched regional ischemia on LV function.
  • To evaluate the sensitivity of the sine wave model in detecting and quantifying ischemic dyssynchrony.

Main Methods:

  • Used a canine model with anesthetized open-chest dogs (n=10).
  • Measured regional and total LV volumes, piezoelectric crystal shortening, and LV pressures.

Related Experiment Videos

  • Induced regional dyskinesis with intracoronary esmolol and matched regional ischemia, defining regional phase angle (alpha).

    • Main Results:

    • Both esmolol and ischemia significantly delayed apical contraction, increasing phase angle (alpha).
    • Regional effective stroke volume (SV) decreased significantly with both esmolol and ischemia.
    • Dobutamine infusion increased the homogeneity of regional phase angles.

    Conclusions:

    • Intracoronary esmolol and regional ischemia induce similar mechanical effects on myocardial function.
    • A sine wave model estimating regional effective SV is sensitive for detecting and quantifying ischemic dyssynchrony.
    • Phase angle and regional amplitude analyses may effectively measure benefits of resynchronization therapies.