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Synergy between the pre-T cell receptor and Notch: cementing the alphabeta lineage choice

Cynthia J Guidos1

  • 1Program in Developmental Biology, Hospital for Sick Children Research Institute, and Department of Immunology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada M5G 1L7. Cynthia.guidos@sickkids.ca

The Journal of Experimental Medicine
|September 27, 2006
PubMed

Notch1 signaling suppresses B cell development and promotes T lineage commitment in thymus-seeding hematopoietic progenitors. Notch1 is also activated in early T cell progenitors, but the functions of these later Notch signals have not been clearly defined. Recent studies reveal that Notch signaling is not essential for pre-T cell receptor (TCR) expression or gammadelta lineage choice. Rather, pre-TCR signaling enhances progenitor competitiveness for limiting Notch ligands, leading to preferential expansion of TCRbeta-bearing progenitors.

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