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Positive association between plasma fibrinogen level and incident hypertension among men: population-based cohort

Anoop Shankar1, Jie Jin Wang, Elena Rochtchina

  • 1Department of Community, Occupational, and Family Medicine, National University of Singapore, Singapore. ashankar@nus.edu.sg

Hypertension (Dallas, Tex. : 1979)
|September 27, 2006
PubMed

Elevated plasma fibrinogen is implicated in cardiovascular disease. However, it is not clear whether fibrinogen levels predict the development of hypertension. We examined the relationship between plasma fibrinogen level and hypertension in a population-based cohort study of 3654 participants (mean age: 61.5 years; range: 49 to 84 years) at the baseline examination (1992-1994) in the Blue Mountains region, west of Sydney, Australia, who were examined 5 years (1997-1999) later. Main outcomes of interest were prevalent hypertension (systolic blood pressure >or=140 mm Hg, diastolic blood pressure >or=90 mm Hg, or a combination of self-reported hypertension diagnosis and use of antihypertensive medications) at baseline (n=2212/3180) and 5-year incidence of hypertension among baseline normotensive individuals (n=361/637). Elevated plasma fibrinogen level was positively associated with prevalent hypertension both among men and women and positively associated with 5-year incident hypertension among men, independent of several cardiovascular risk factors. Multivariable odds ratio (95% CI) of 5-year incident hypertension comparing tertile 3 of plasma fibrinogen (>or=3.9 g/L) with tertile 1 (

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