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Updated: Jul 19, 2026
Scoring Central Nervous System Inflammation, Demyelination, and Axon Injury in Experimental Autoimmune Encephalomyelitis
Published on: February 23, 2024
CSF neurofilament levels: a potential prognostic marker in Guillain-Barré syndrome
A Petzold1, N Hinds, N M F Murray
1Department of Neuroimmunology, Institute of Neurology and Tavistock Intensive Care Unit, National Hospital for Neurology and Neurosurgery, London, UK. a.petzold@ion.ucl.ac.uk
Abstract:
Long-term morbidity from Guillain-Barré syndrome (GBS) is caused by axonal damage. This prospective study demonstrated that neurofilaments (NfHs), a biomarker for axonal damage, were of prognostic value in GBS. CSF NfH levels correlated with the F score and Medical Research Council summed score and were higher in patients with neurophysiologic evidence of axonal degeneration compared to those without. Pathologically high CSF NfH levels (>0.73 ng/mL) predicted worse motor and functional outcome.