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Monoclonal antibodies from plants: a new speed record

Andrew Hiatt1, Michael Pauly

  • 1Mapp Biopharmaceutical, Inc., 6160 Lusk Boulevard, C105, San Diego, CA 92121, USA.

Proceedings of the National Academy of Sciences of the United States of America
|September 27, 2006
PubMed
Abstract

No abstract available in PubMed .

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Hybridoma technology is used for the large-scale production of monoclonal antibodies. Monoclonal antibodies bind to only a single antigenic determinant or epitope. Such antibodies are used in research, diagnostics, and disease therapy. The hybridoma technology established in 1975 by Georges Köhler and Cesar Milstein was awarded the Nobel Prize in Medicine in 1984 for revolutionizing research and therapy.
Hybridoma Selection
Commonly used fusion techniques — electroporation, polyethylene glycol...