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Updated: Jul 19, 2026

Combining Chemical Cross-linking and Mass Spectrometry of Intact Protein Complexes to Study the Architecture of Multi-subunit Protein Assemblies
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Combining Chemical Cross-linking and Mass Spectrometry of Intact Protein Complexes to Study the Architecture of Multi-subunit Protein Assemblies

Published on: November 28, 2017

The impact of protein characterization in structural proteomics

Arie Geerlof1, J Brown, B Coutard

  • 1EMBL Hamburg Outstation, Notkestrasse 85, Hamburg, Germany. arie.geerlof@embl-hamburg.de

Acta Crystallographica. Section D, Biological Crystallography
|September 27, 2006
PubMed
Summary

This study introduces a protein characterization strategy for structural proteomics, emphasizing quality assessment before crystallization. It recommends purity thresholds to improve protein production and crystallization success rates.

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