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High-Throughput Screening to Obtain Crystal Hits for Protein Crystallography
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Published on: March 10, 2023

SPINE high-throughput crystallization, crystal imaging and recognition techniques: current state, performance

Ian M Berry1, O Dym, R M Esnouf

  • 1Division of Structural Biology and Oxford Protein Production Facility (OPPF), Wellcome Trust Centre for Human Genetics, Oxford, England.

Acta Crystallographica. Section D, Biological Crystallography
|September 27, 2006
PubMed

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Determination of Crystal Structures01:29

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In the late 1800s, the revelation that light extended beyond visible wavelengths led to the discovery of X-rays by Wilhelm Roentgen. Recognized as high-energy electromagnetic radiation with short wavelengths, X-rays prompted exploration into their interaction with crystals. Max von Laue proposed in 1912 that the periodic arrangement of atoms, ions, or molecules in crystals would cause them to diffract X-rays, a hypothesis confirmed through experiments with copper sulfate and zinc sulfide...