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SPINE high-throughput crystallization, crystal imaging and recognition techniques: current state, performance

Ian M Berry¹, O Dym, R M Esnouf

¹Division of Structural Biology and Oxford Protein Production Facility (OPPF), Wellcome Trust Centre for Human Genetics, Oxford, England.

Acta Crystallographica. Section D, Biological Crystallography

|September 27, 2006

Summary

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This summary is machine-generated.

High-throughput and nanolitre-scale protein crystallography technologies have been successfully adopted by Structural Proteomics In Europe (SPINE) partners. This revolutionizes structural biology methods and sets the stage for future crystallization advancements.

Area of Science:

Structural biology
Biochemistry
Biophysics

Background:

The Structural Proteomics In Europe (SPINE) project commenced in October 2002.
Workpackage 4 focused on advancing protein crystallography technologies.

Purpose of the Study:

To review developments in high-throughput and nanolitre-scale protein crystallography.
To assess the adoption and impact of new technologies within the SPINE project.

Main Methods:

Surveying the uptake and use of novel technologies by SPINE partners across Europe.
Analyzing partner experiences with new working methods.

Main Results:

Highly successful adoption of innovative protein crystallography techniques was observed.

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New methods are revolutionizing the field of structural biology.

Conclusions:

The implementation of advanced protein crystallography technologies has been effective.
Future developments in crystallization methodologies are anticipated.