Related Experiment Video
Updated: Jul 19, 2026
06:50
The Automated Crystallography Pipelines at the EMBL HTX Facility in Grenoble
Published on: June 5, 2021
High-throughput sample handling and data collection at synchrotrons: embedding the ESRF into the high-throughput
A Beteva1, F Cipriani, S Cusack
1ESRF, 6 Rue Jules Horowitz, Grenoble, France.
Acta Crystallographica. Section D, Biological Crystallography
|September 27, 2006
Summary
A new automated data collection system was installed at the European Synchrotron Radiation Facility (ESRF) to streamline protein structure determination. This system enables remote control and automated sample handling for efficient data acquisition.
Area of Science:
- Structural biology
- Biophysics
- Synchrotron science
Background:
- Automated data collection is crucial for high-throughput structural proteomics.
- The European Synchrotron Radiation Facility (ESRF) supports structural biology research.
- Developing automated pipelines enhances experimental efficiency.
Purpose of the Study:
- To implement and install an automated data-collection system at the ESRF.
- To integrate this system into the SPINE automated structure-determination pipeline.
- To enable remote operation and comprehensive data management.
Main Methods:
- Installation of an automated system on multiple beamlines (seven insertion-device, one bending-magnet).
- Integration with beamline control systems for remote interaction.
- Automated sample mounting, alignment, characterization, data collection, and processing.
Main Results:
- Successful implementation across eight beamlines at the ESRF.
- Enabled remote control of experimental procedures.
- Automated sample handling and data processing were achieved.
Conclusions:
- The automated data-collection system significantly advances the SPINE pipeline.
- This system enhances efficiency and accessibility for structural proteomics research.
- Remote operation and data reporting improve experimental workflow.
