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Relationship of classical and non-classical risk factors with genetic variants relevant to coronary heart disease

Josep Maria Manresa1, Alberto Zamora, Marta Tomás

  • 1Unitat de Lípids i Epidemiologia Cardiovascular, Institut Municipal d'Investigació Mèdica, Barcelona, Spain.

European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology
|September 27, 2006
PubMed

Insights

Genetic variants in PPAR-alpha, LPL, and TNF-alpha influence cardiovascular risk factors like lipid levels, inflammation, and oxidative status in the Mediterranean population.

Area of Science:

  • Cardiovascular Genetics
  • Atherothrombosis Research
  • Population Health

Background:

  • Atherothrombosis development is linked to established cardiovascular risk factors, with emerging evidence for genetic and non-classical factors.
  • Investigating these factors is crucial for understanding disease progression in diverse populations.

Purpose of the Study:

  • To determine the association between classical and non-classical cardiovascular risk factors and candidate gene polymorphisms in a Mediterranean population.
  • To explore the role of specific gene variants in cardiovascular risk.

Main Methods:

  • A cross-sectional study was conducted on a general Mediterranean population.
  • Prevalence of classical (lipids, blood pressure, BMI, etc.) and non-classical (CRP, oxidative status, etc.) risk factors was assessed.
  • Associations with five gene polymorphisms (ATP-binding cassette transporter A1, PPAR-alpha, LPL, PON1, TNF-alpha) were analyzed.

Main Results:

  • PPAR-alpha-V and LPL-H alleles correlated with lower HDL-c and higher cholesterol/triglyceride ratios.
  • The PPAR-alpha-V allele was linked to elevated C-reactive protein.
  • Homozygotes for LPL-H and TNF-alpha-G alleles exhibited higher oxidative status.

Conclusions:

  • Genetic variants PPAR-alpha-L162V, LPL-HindIII, and TNF-alpha-G-308A are associated with non-classical cardiovascular risk factors.
  • These genetic factors impact lipid profiles, inflammation, and oxidative status, contributing to atherothrombosis risk.
Abstract

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