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Related Experiment Videos

From genes to behavior in developmental dyslexia.

Albert M Galaburda1, Joseph LoTurco, Franck Ramus

  • 1Department of Neurology, Division of Behavioral Neurology, Harvard Medical School, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA. agalabur@bidmc.harvard.edu

Nature Neuroscience
|September 27, 2006
PubMed
Summary

Genetic links to developmental dyslexia involve brain development, potentially causing early auditory and cognitive deficits. These brain changes may underlie phonological processing issues characteristic of dyslexia.

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Area of Science:

  • Neuroscience
  • Genetics
  • Developmental Psychology

Background:

  • Four genes associated with developmental dyslexia are implicated in brain development.
  • Brain development abnormalities are frequently observed in individuals with dyslexia.
  • Induced brain abnormalities in rodent models lead to auditory and cognitive deficits.

Purpose of the Study:

  • To propose a pathway linking genetic factors to developmental brain changes and subsequent deficits in dyslexia.
  • To explore the role of developmental brain abnormalities in the phonological and auditory processing deficits seen in dyslexia.

Main Methods:

  • Review of existing literature on genes, brain development, and dyslexia.
  • Comparative analysis of human dyslexia studies and rodent models of brain abnormalities.

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Main Results:

  • Genes linked to dyslexia play a role in brain development.
  • Developmental brain abnormalities can manifest as auditory and cognitive deficits.
  • Auditory processing abnormalities may resolve during development but contribute to early phonological deficits.

Conclusions:

  • A proposed pathway exists from genetic effects to developmental brain changes, leading to perceptual and cognitive deficits in dyslexia.
  • Early auditory processing deficits, potentially stemming from developmental brain changes, may contribute to the phonological disorder in dyslexia.