Fragile X syndrome and autism at the intersection of genetic and neural networks
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Matthew K Belmonte1, Thomas Bourgeron
1Department of Human Development, Cornell University, Martha Van Rensselaer Hall, Ithaca, New York 14853-4401, USA. belmonte@mit.edu
Abstract:
Autism, an entirely behavioral diagnosis with no largely understood etiologies and no population-wide biomarkers, contrasts with fragile X syndrome (FXS), a single-gene disorder with definite alterations of gene expression and neuronal morphology. Nevertheless, the behavioral overlap between autism and FXS suggests some overlapping mechanisms. Understanding how the single-gene alteration in FXS plays out within complex genetic and neural network processes may suggest targets for autism research and illustrate strategies for relating autism to more singular genetic syndromes.
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