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Flutamide in hormone-resistant prostatic cancer.

S D Fosså¹, G Hosbach, E Paus

¹Department of Medical Oncology, Norwegian Radium Hospital, Oslo.

The Journal of Urology

|December 1, 1990

Summary

Flutamide showed subjective improvement in some patients with hormone-resistant prostate cancer. Further phase 3 studies are needed to confirm its effectiveness and role in managing this condition.

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Area of Science:

Oncology
Pharmacology

Background:

Hormone-resistant prostate cancer (HRPC) presents a significant clinical challenge.
Effective treatment options for HRPC, particularly those improving subjective symptoms and survival, are limited.

Purpose of the Study:

To evaluate the efficacy and toxicity of flutamide in patients with hormone-resistant prostate cancer.
To assess the correlation between prostate-specific antigen (PSA) decline and survival outcomes.

Main Methods:

A cohort of 25 fully evaluable patients with HRPC received flutamide (250 mg orally 3 times daily).
Subjective response, PSA levels, and toxicity were monitored.
Correlation between PSA decrease and survival was analyzed.

Main Results:

Flutamide yielded a subjective response in 5 of 25 patients (20%).
A ≥40% decrease in PSA was observed in 7 of 24 patients (29%), correlating with improved survival.
Gastrointestinal toxicity led to discontinuation in 5 patients.

Conclusions:

Flutamide may offer a role in managing HRPC for symptom relief and potential survival benefit.
Further phase 3 trials are essential to validate flutamide's effectiveness, especially against less expensive alternatives.

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