Saccharomyces cerevisiae S288C genome annotation: a working hypothesis

Area of Science:

• * Genomics
• * Molecular Biology
• * Bioinformatics

Background:

• * The *Saccharomyces cerevisiae* (baker's yeast) genome is a fundamental model organism in eukaryotic research.
• * Its initial annotation in 1996 has undergone continuous updates due to new discoveries.
• * The Saccharomyces Genome Database (SGD) is the central resource for yeast genome information.

Purpose of the Study:

• * To review the evolution of the *S. cerevisiae* genome sequence and annotation over a decade.
• * To highlight the data sources and methodologies used for annotation refinement.
• * To celebrate the 10th anniversary of the *S. cerevisiae* genome sequence completion.

Main Methods:

• * Integration of diverse experimental data (e.g., transcriptomics, proteomics).
• * Utilization of comparative genomics across related species.
• * Development and application of rigorous data evaluation and curation pipelines at SGD.

Main Results:

• * Significant changes in the *S. cerevisiae* genome sequence and annotation have occurred since 1996.
• * Annotation updates are based on a combination of experimental evidence and computational predictions.
• * SGD employs a systematic approach to incorporate and document new genomic data.

Conclusions:

• * The *S. cerevisiae* genome annotation is a dynamic, evolving resource.
• * Continuous refinement ensures the accuracy and utility of this vital model organism genome.
• * SGD plays a crucial role in maintaining a high-quality, community-supported yeast genome database.