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Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure
Published on: August 25, 2017
[COPD--chronic obstructive pulmonary disease and its implications for the human organism]
D A Groneberg1, D Pleimes, H Golpon
1Abteilung Pneumologie, Zentrum für Innere Medizin, Medizinische Hochschule Hannover.
Abstract:
Chronic obstructive pulmonary disease (COPD) belongs next to bronchial asthma to the most important diseases of the respiratory tract in terms of its socio-economic impact. Especially exacerbations of COPD and clinical end-stages exert extremely negative effects on the global burden of disease. This article analyses current aspects of COPD regarding epidemiology, pathogenesis, pathophysiology and diagnosis of the disease. Given the estimation that COPD will be the third most common cause of death in the year 2020, the high socio-economic costs and the primary cause tobacco smoke exposure, the disease can be regarded as extremely relevant for numerous aspects of insurance medicine.
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