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Updated: Jul 23, 2026

Intralymphatic Immunotherapy and Vaccination in Mice
Published on: February 2, 2014
Allergy treatment with a peptide vaccine
D R Stanworth1, V M Jones, I V Lewin
1Department of Immunology, University of Birmingham Medical School, UK.
Abstract:
An antiserum, obtained by immunising rabbits with a human peptide-protein conjugate, was shown to inhibit histamine release from rat mast cells both in vitro and in vivo. Immunisation of sensitised rats with the same peptide reduced IgE antibody formation and serum histamine concentration, and abolished systemic anaphylactic reactions in response to allergen challenge. This peptide may form the basis of a vaccine in a new approach to the immunotherapy of atopic disease.
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