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Related Experiment Videos

Stable genes.

J V Frei1

  • 1Department of Pathology, University of Western Ontario, London, Canada.

Medical Hypotheses
|August 1, 1990
PubMed
Summary

Conserved genes with multiple genome copies may be protected by novel

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Area of Science:

  • Genomics
  • Molecular Biology
  • Evolutionary Biology

Background:

  • Certain genes, like those for histones and RNAs, are highly conserved throughout evolution.
  • These conserved genes often exist as numerous tandem repeat copies within the genome.

Purpose of the Study:

  • To propose a novel mechanism for sequence conservation in highly repetitive genomic regions.
  • To introduce the concept of 'polystrand' enzymes in maintaining genetic integrity.

Main Methods:

  • Theoretical proposal based on existing knowledge of gene conservation and genome structure.
  • Hypothesizing the function of as-yet-undetected enzymes.

Main Results:

  • Identified a potential role for multiple gene copies in sequence conservation.
  • Proposed that 'polystrand' enzymes could compare and correct errors among repetitive sequences.

Conclusions:

  • Multiple tandem repeat copies of conserved genes may serve as a template for error correction.
  • The existence and function of 'polystrand' enzymes are hypothesized as a mechanism for maintaining genetic fidelity in repetitive DNA sequences.