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Post-operative aspergillosis

A C Pasqualotto1, D W Denning

  • 1School of Medicine, The University of Manchester and Wythenshawe Hospital, Manchester, UK.

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
|September 28, 2006
PubMed

Insights

Post-operative aspergillosis, a fungal infection, can occur in immunocompetent patients after surgery. Early diagnosis and treatment, including antifungal therapy, are crucial for better outcomes.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Surgical Infections

Background:

  • Invasive aspergillosis typically affects immunocompromised individuals.
  • Surgical site infections caused by Aspergillus have been reported in immunocompetent patients.

Purpose of the Study:

  • To review and analyze reported cases of post-operative aspergillosis.
  • To identify common surgical procedures associated with this infection.
  • To discuss prevention and treatment strategies.

Main Methods:

  • Systematic literature search of Medline, LILACS, and EMBASE databases.
  • Review of references from relevant articles and conference abstracts.
  • Analysis of over 500 reported cases of post-operative aspergillosis.

Main Results:

  • Cardiac, ophthalmological, and dental surgeries were most frequently associated with post-operative aspergillosis.
  • Other involved surgeries included orthopedic, vascular prosthetic, abdominal, and neurosurgery.
  • Airborne infection during surgery is the presumed source in most cases.

Conclusions:

  • Prevention requires stringent operating room ventilation control.
  • Prompt diagnosis, surgical debridement, and antifungal therapy (e.g., voriconazole) are essential for successful treatment.
  • Improved diagnostic methods are needed, especially for endocarditis and aortitis.

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