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Comparison of secular trends in pneumococcal serotypes causing invasive disease in Denver, Colorado (1971-2004) and

D Akduman1, J M Ehret, F N Judson

  • 1Zonguldak Karaelmas University, Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology, Zonguldak, Turkey.

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
|September 28, 2006
PubMed

Insights

Pneumococcal serotypes in Denver showed shifts over 30 years. While vaccines cover most strains, specific serotypes like 14, 3, 6, 9, and 19 require ongoing surveillance for effective prevention.

Area of Science:

  • Microbiology
  • Epidemiology
  • Vaccinology

Background:

  • Invasive pneumococcal disease (IPD) remains a significant public health concern.
  • Serotype distribution of Streptococcus pneumoniae is dynamic and can vary geographically and temporally.
  • Understanding serotype prevalence is crucial for evaluating vaccine effectiveness and guiding public health strategies.

Purpose of the Study:

  • To analyze the temporal trends of pneumococcal serotypes causing invasive infections in Denver, Colorado, from 1971 to 2004.
  • To assess the coverage of existing pneumococcal vaccines against prevalent serotypes identified during the study period.

Main Methods:

  • Retrospective analysis of invasive pneumococcal isolates from three Denver hospitals.
  • Serotyping of isolates collected between 1971 and 2004.
  • Comparison of serotype prevalence across different time periods and assessment of vaccine coverage.

Main Results:

  • Streptococcus pneumoniae serotype 14 was the most common (13.2%), followed by serotypes 3, 4, 6, 9, and 19 (44.1% combined).
  • Pneumococcal polysaccharide vaccine (PPSV) covered all prevalent serotypes (91.3% of isolates), while pneumococcal conjugate vaccine (PCV) covered 79.1% of prevalent serotypes (56.7% of isolates).
  • Serotypes 6, 9, and 14 showed increased prevalence in the last decade (37.3%) compared to the first (20.2%), while serotypes 3 and 23 decreased (18.5% vs. 11.0%).

Conclusions:

  • Significant shifts in pneumococcal serotype prevalence occurred in Denver between 1971 and 2004.
  • While current vaccines offer broad coverage, the changing epidemiology necessitates ongoing monitoring.
  • The rise of specific serotypes highlights the need for updated vaccination strategies and continued surveillance.

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