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Related Concept Videos

Structure and Function of Platelets01:18

Structure and Function of Platelets

The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000 platelets, with...

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Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System
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Viability and function of 8-day-stored apheresis platelets.

Sherrill J Slichter1, Doug Bolgiano, Mary Kay Jones

  • 1Puget Sound Blood Center, Seattle, Washington 98104-1256, USA. sjslichter@psbc.org

Transfusion
|September 28, 2006
PubMed
Summary

Extended storage of apheresis platelets (PLTs) is feasible. Eight-day stored PLTs met quality standards, showing acceptable in vivo recovery and survival, supporting longer platelet shelf life.

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Area of Science:

  • Hematology
  • Transfusion Medicine
  • Platelet Biology

Background:

  • Platelet storage duration is limited by quality concerns.
  • Bacterial detection and pathogen inactivation methods may enable extended platelet storage.

Purpose of the Study:

  • To evaluate the in vivo quality of apheresis-collected platelets (PLTs) after 8 days of storage.
  • To determine if stored PLTs meet proposed poststorage quality standards.

Main Methods:

  • Collected autologous platelets (PLTs) from 20 volunteers using apheresis.
  • Performed in vitro function and metabolic assays on Day 0 and Day 8.
  • Radiolabeled fresh and stored PLTs with (51)Cr or (111)In for transfusion.
  • Assessed posttransfusion recovery and survival of fresh versus stored PLTs.

Main Results:

  • In vitro assays showed expected ranges for fresh and stored PLTs.
  • Mean PLT recovery was 66% (fresh) vs. 53% (stored).
  • Mean PLT survival was 8.5 days (fresh) vs. 5.6 days (stored).
  • No significant differences in in vivo data between trial sites or radiolabels.

Conclusions:

  • Autologous apheresis platelets stored for 8 days meet proposed in vivo quality standards for poststorage recovery and survival.
  • Extended storage of platelets is viable with current methods.
  • Findings support the potential for longer platelet shelf life.