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Related Experiment Videos

Hypothalamic hormone interaction in acromegaly.

A Gomez-Pan, W M Tunbridge, A Duns

    Clinical Endocrinology
    |September 1, 1975
    PubMed
    Summary

    Synthetic hypothalamic hormones can stimulate growth hormone (GH) release in acromegaly patients. This GH release is not mediated by thyroid-stimulating hormone (TSH) and may indicate altered receptor specificity.

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    Area of Science:

    • Endocrinology
    • Molecular Endocrinology
    • Neuroendocrinology

    Background:

    • Acromegaly is characterized by excessive growth hormone (GH) production.
    • The role of hypothalamic hormones in regulating GH in acromegaly requires further elucidation.

    Purpose of the Study:

    • To investigate the growth hormone (GH) response to synthetic hypothalamic hormones in patients with acromegaly.
    • To determine if GH release is mediated by thyroid-stimulating hormone (TSH) and explore receptor specificity.

    Main Methods:

    • Eleven acromegaly patients received synthetic thyrotrophin-releasing hormone (TRH) and luteinizing hormone/follicle-stimulating hormone releasing hormone (LHRH).
    • Growth hormone (GH), thyrotropin (TSH), and luteinizing hormone/follicle-stimulating hormone (LH/FSH) levels were monitored.

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  • The effect of growth hormone release-inhibiting hormone (somatostatin) on TRH-induced GH release was assessed.

    • Main Results:

    • Eight out of eleven patients exhibited a GH response to TRH; three did not.
    • The GH response to TRH was independent of the TSH response to TRH.
    • Growth hormone release-inhibiting hormone suppressed TRH-mediated GH release.
    • LHRH elicited a GH response in four patients, though it was minimal in three.

    Conclusions:

    • Thyrotrophin-releasing hormone (TRH) can stimulate GH release in acromegaly, independent of TSH.
    • The observed GH release suggests a loss of specificity in somatotroph receptor sites for hypothalamic hormones in acromegaly.
    • These findings highlight potential therapeutic targets and diagnostic insights in acromegaly management.