Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hole-enhanced Raman scattering.

John T Bahns1, Funing Yan, Dengli Qiu

  • 1Biosciences Division, Argonne National Laboratory, Argonne, Illinois 60439, USA.

Applied Spectroscopy
|September 28, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Survivin-Sodium Iodide Symporter Reporter as a Non-Invasive Diagnostic Marker to Differentiate Uterine Leiomyosarcoma from Leiomyoma.

Cells·2023
Same author

Microphase separation of a quadruple hydrogen bonding supramolecular polymer: effect of the steric hindrance of the ureido-pyrimidone on their viscoelasticity.

RSC advances·2022
Same author

Using a biocompatible diazidecrosslinker to fabricate a robust polyelectrolyte multilayer film with enhanced effects on cell proliferation.

Journal of materials chemistry. B·2020
Same author

Robotic-Assisted Roux-en-Y Gastric Bypass: Learning Curve Assessment Using Cumulative Sum and Literature Review.

Bariatric surgical practice and patient care·2019
Same author

Direct Experimental Observation of Facet-Dependent SERS of Cu<sub>2</sub> O Polyhedra.

Small (Weinheim an der Bergstrasse, Germany)·2017
Same author

Mechanical regulation of organ asymmetry in leaves.

Nature plants·2017

This study introduces hole-enhanced Raman scattering (HERS) for aqueous samples, achieving high signal-to-noise ratios. HERS offers superior performance and reproducibility compared to conventional methods, enabling quantitative analysis of biological molecules.

Area of Science:

  • Nanophotonics
  • Surface-Enhanced Spectroscopy
  • Raman Spectroscopy

Background:

  • Conventional surface-enhanced Raman scattering (SERS) using gold nanoparticles faces limitations in reproducibility and substrate stability.
  • Developing robust and sensitive substrates is crucial for quantitative molecular analysis.

Purpose of the Study:

  • To report the first Stokes and anti-Stokes non-resonant hole-enhanced Raman scattering (HERS) spectra for aqueous R6G molecules.
  • To compare HERS performance with conventional SERS and identify optimal parameters for HERS gain.

Main Methods:

  • Adsorption of R6G molecules onto random nanoholes in thin gold films.
  • Acquisition of high signal-to-noise ratio (S/N) HERS spectra in the aqueous phase.
  • Correlation of hole density with Raman scattering gain to determine optimal HERS parameters.

Related Experiment Videos

Main Results:

  • HERS demonstrated higher strength gain, exceptional reproducibility, and excellent mechanical stability compared to SERS from gold colloid particles.
  • Optimum HERS gain was determined for 50 nm diameter holes at approximately 100 holes/µm².
  • Uniform "hot spots" were provided by the nanoholes, enhancing Raman scattering.

Conclusions:

  • HERS offers a simple, reliable, and highly effective alternative to conventional SERS for aqueous samples.
  • The developed HERS substrate shows significant potential for enabling quantitative Raman analysis of biological molecules.