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Synthesis of chlorambucil-tempol adduct and its delivery using fluoroalkyl double-ended poly (ethylene glycol)
Anuja Prabhutendolkar1, Xiangli Liu, Errol V Mathias
1Department of Chemistry and Biochemistry, California State University Los Angeles, Los Angeles, CA 90032, USA.
Abstract:
In our pursuit to find potent anticancer drugs, we have covalently bonded free radical tempol to chlorambucil giving a chlorambucil-tempol (CT) adduct in which both of the anticancer active sites in tempol and chlorambucil were left intact. Analysis using NMR, Maldi-TOF, and EPR verified the designed chemical structure. Because the CT adduct is more hydrophobic than chlorambucil, its delivery also was investigated using fluoroalkyl double-ended poly (ethylene glycol) (Rf-PEG) micelles. Results from EPR spectra and(19) F and(1) H NMR spin lattice relaxation times show that the Rf-PEG micelles are able to encapsulate CT into the Rf cores of the micelles.
