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Updated: Jul 19, 2026

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
Published on: January 17, 2018
Pituitary hyperplasia
Mubarak Al-Gahtany1, Eva Horvath, Kalman Kovacs
1Department of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada. mubarak.al-gahtany@utoronto.ca
Abstract:
Pituitary hyperplasia is rare, difficult to diagnose and sometimes controversial. The hyperplasia could be physiologic which is usually reversible, or pathologic which varies in presentation from incidental to tumor like lesion with and without hormonal disturbance. Any pituitary cell is capable of undergoing hyperplasia in the presence of the right stimuli. In this article we summarize the various pathologic and morphologic features of each subtype of pituitary hyperplasia, give an account of the molecular, hormonal and cellular basis of this condition and outline its clinical significance, differential diagnosis and prognosis.
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