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Guidelines for establishing a maternal serum alpha-fetoprotein screening program.

F H Wians1, G D Hankins, E R Yeomans

  • 1Department of Pathology, Wilford Hall USAF Medical Center/SGHOLCC, Lackland AFB, San Antonio, TX 78236-5300.

Military Medicine
|October 11, 1990
PubMed
Summary
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Maternal serum alpha-fetoprotein (MSAFP) screening is a standard obstetric care. This report reviews clinical and analytical factors for establishing an on-site MSAFP screening program versus using a reference laboratory.

Area of Science:

  • Obstetrics and Gynecology
  • Clinical Chemistry
  • Laboratory Medicine

Background:

  • Maternal serum alpha-fetoprotein (MSAFP) screening is a standard of care for pregnant women between 15-20 weeks gestation.
  • Decisions regarding in-house versus reference laboratory testing involve various clinical and financial considerations.

Purpose of the Study:

  • To review the clinical and analytical aspects of MSAFP testing.
  • To provide guidelines for establishing an on-site MSAFP screening program.

Main Methods:

  • Review of clinical and analytical parameters for MSAFP testing.
  • Analysis of factors influencing the decision between in-house and reference laboratory testing.

Main Results:

  • Discussion of key performance indicators for MSAFP assays.

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  • Consideration of cost-effectiveness and logistical requirements for on-site programs.

    • Conclusions:

    • Establishing an on-site MSAFP screening program requires careful evaluation of clinical, analytical, and operational factors.
    • Guidelines are provided to assist in the decision-making process for implementing such programs.