Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The lymphotoxin pathway: beyond lymph node development.

Douglas D McCarthy1, Leslie Summers-Deluca, Frances Vu

  • 1Department of Immunology, University of Toronto, 1 King's College Circle Toronto, Ontario, Canada.

Immunologic Research
|September 28, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Interfacial Active-Oxygen Transport in Inverse CuO<sub><i>x</i></sub>/Perovskite Catalysts for Low-Temperature CO Oxidation.

ACS applied materials & interfaces·2026
Same author

The impact of facial expressions on space- and object-based attention by gaze cues.

Cognitive processing·2026
Same author

Revealing the Action Mechanism of the FOXA2-LAMC2 Axis in Driving Cisplatin Resistance of Head and Neck Squamous Cell Carcinoma via Based Multi-Omic Analysis and Experimental Validation.

Chemical biology & drug design·2026
Same author

Biodegradable microplastics influence on organic component microbial transformation during sludge composting.

Frontiers in microbiology·2026
Same author

The General Mechanism of Status: The Impact of Perceptual and Knowledge-Based Social Status on Selective Attention.

Behavioral sciences (Basel, Switzerland)·2026
Same author

Novel Systemic Inflammatory Indices (SII and SIRI) as Mediators Between BMI and Hearing Loss.

Mediators of inflammation·2026
Same journal

Emapalumab plus conventional therapy with or without ruxolitinib for pediatric hemophagocytic lymphohistiocytosis: a single center retrospective study.

Immunologic research·2026
Same journal

Immunological spectrum in patients with thymoma: beyond good syndrome.

Immunologic research·2026
Same journal

Microbiome immune crosstalk in Sjögren's syndrome: mechanistic insights and translational perspectives.

Immunologic research·2026
Same journal

Immune checkpoint inhibitor-induced myasthenia gravis and myocarditis: a fatal immune-related adverse event.

Immunologic research·2026
Same journal

TRIM28 and TRIM32: multifaceted regulators of innate immunity and antiviral defence.

Immunologic research·2026
Same journal

Decoding PANoptosis: Crosstalk of cell death pathways in immunity and inflammation.

Immunologic research·2026
See all related articles

Lymphotoxin-beta receptor (LTbetaR) signaling is essential for immune organ development and adult immune responses. This review explores LTbetaR

Area of Science:

  • Immunology
  • Developmental Biology

Background:

  • Lymphotoxin-beta receptor (LTbetaR) signaling is crucial for lymph node and Peyer's patch development.
  • LTbetaR signaling maintains stromal cell types and chemokine expression in adult lymphoid tissues.

Purpose of the Study:

  • To investigate the role of LTbetaR signaling in initiating immune responses.
  • To explore LTbetaR's regulation of humoral and cellular immunity beyond its organizational role.

Main Methods:

  • Review of existing literature on LTbetaR signaling.
  • Analysis of studies involving mice deficient in lymphotoxin-alpha (LTalpha), LTbeta, and LTbetaR.

Main Results:

  • LTbetaR signaling is critical for embryonic development of lymphoid organs.

Related Experiment Videos

  • LTbetaR signaling influences adult immune homeostasis and specialized stromal cell maintenance.

    • Conclusions:

    • LTbetaR signaling has multifaceted roles in immunity, impacting both lymphoid tissue organization and direct immune response initiation.
    • Further research into LTbetaR's complex regulatory functions in humoral and cellular immunity is warranted.