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Antibody diversification: mutational mechanisms and oncogenesis

Darina Frieder1, Mani Larijani, Ephraim Tang

  • 1Department of Immunology, University of Toronto, Medical Sciences Bldg., Toronto, Canada.

Immunologic Research
|September 28, 2006
PubMed
Summary

Antibody diversification, including somatic hypermutation, gene conversion, and class switch recombination (CSR), enhances immune defense against pathogens. This review explores these processes, their role in lymphomagenesis, and outstanding research questions.

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