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Updated: Jul 19, 2026
Biological Compatibility Profile on Biomaterials for Bone Regeneration
Published on: November 16, 2018
Delayed extrusion of hydroxyapatite after transpetrosal reconstruction
Kumaresh Krishnamoorthy1, Myles L Pensa, Ravi N Samy
1The Neurosciences Institute (TNI), Department of Otolaryngology, University of Cincinnati/Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. meymorch@privat.dk
Objectives:
: To review the long-term results of hydroxyapatite closure of transpetrosal defects.
Study Design:
: Retrospective chart review.
Methods:
: One hundred seventy-seven patients were followed for more than 5 years. After surgical management by way of transpetrosal routes, hydroxyapatite was placed after medial wound closure with abdominal fat and before a three-layered lateral soft tissue closure.
Results:
: Among this group of patients, three (1.7%) cerebrospinal fluid (CSF) leaks were encountered. None of these required re-operation. Delayed extrusion of hydroxyapatite with concomitant superficial wound infections have occurred in seven (4%) patients. All required operative re-intervention.
Conclusions:
: Hydroxyapatite has proven to be an effective material in the closure of skull base defects. Nevertheless, delayed extrusion of this agent can occur, resulting in the potential for morbidity and the need for operative re-intervention.
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