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Updated: Jul 19, 2026

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone
Published on: September 9, 2020
A paranasal tumor associated with tumor-induced osteomalacia
Go Inokuchi1, Hitoshi Tanimoto, Haruhiko Ishida
1Department of Otorhinolaryngology-Head and Neck Surgery, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
Background:
Tumor-induced osteomalacia (TIO) is an extremely rare paraneoplastic syndrome associated with mesenchymal tumors in the craniofacial region.
Methods:
We treated a 24-year-old Japanese woman with paranasal sinus tumor and a low serum phosphate level who presented with nasal obstruction and systemic bone fractures. Serum fibroblast growth factor 23 (FGF-23) was measured before and after surgery.
Results:
After surgery, her symptoms were resolved and the serum phosphate and FGF-23 levels became normalized.
Conclusion:
FGF-23 is thought to be a useful diagnostic marker in patients with craniofacial tumors associated with multiple systemic fractures.
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