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Updated: Jul 19, 2026

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis
Published on: April 25, 2022
Are microRNAs located in genomic regions associated with cancer?
P Lamy1, C L Andersen, L Dyrskjøt
1Bioinformatics Research Center (BiRC), University of Aarhus, Hoegh-Guldbergs Gade 10, Bldg 1090, Aarhus C, Denmark.
Abstract:
We report on the location of 283 miRNAs in the human genome in relation to copy number changes in three distinct types of tumours: prostate, bladder and colon. In prostate and colon tumours, we find miRNAs over-represented in regions with copy number gain and under-represented in regions with copy number loss. Surprisingly this pattern appears to be reversed in bladder cancer. We compared our miRNA copy number data to published miRNA expression data; unexpectedly, we did not find a statistically significant relationship between miRNA copy number and expression level. This suggests that miRNA expression is regulated through different mechanisms than mRNA expression.
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