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Published on: March 24, 2022
[Selective retina therapy: methods, technique, and online dosimetry].
R Brinkmann1, G Schüle, J Neumann
1Medizinisches Laserzentrum Lübeck GmbH, Peter-Monnik-Weg 4, 23562 Lübeck, Germany. brinkmann@bmo.uni-luebeck.de
Summary
Selective Retina Therapy (SRT) offers a new, subtle laser treatment for retinal disorders by targeting the retinal pigmentary epithelium (RPE) without damaging surrounding tissues. This method promotes RPE regeneration and avoids vision-impairing scotoma, unlike traditional laser treatments.
Area of Science:
- Ophthalmology
- Biomedical Engineering
- Laser Medicine
Context:
- Degradation of the retinal pigmentary epithelium (RPE) is a key factor in various retinal disorders.
- Conventional laser photocoagulation causes thermal necrosis and scotoma, limiting its therapeutic application.
- Selective Retina Therapy (SRT) emerges as a novel, minimally invasive approach.
Purpose:
- To review the methods and mechanisms of Selective Retina Therapy (SRT) for RPE disorders.
- To evaluate the efficacy of SRT using in vitro and preclinical data across different irradiation settings.
- To introduce an optoacoustic technique for visualizing SRT effects and dosimetry control.
Summary:
- SRT selectively targets the RPE, preserving the neural retina and choroid.
- The therapy aims for RPE regeneration and metabolic enhancement at the chorio-retinal junction.
- Unlike conventional methods, SRT does not result in scotoma formation.
- An optoacoustic technique aids in visualizing subsurface effects and dosimetry.
Impact:
- SRT presents a promising alternative to conventional laser treatments for retinal diseases.
- Potential for RPE regeneration and improved long-term metabolic function.
- Avoidance of scotoma offers a significant advantage for patient vision quality.
- Advanced imaging techniques enhance treatment precision and monitoring.
