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Updated: Feb 27, 2026
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An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
Published on: June 6, 2025
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[Link between rheumatoid arthritis and cancer]
1Div. of Pediatric Rheumatology, Massachusetts General Hospital for Children, MGH Cancer Center and Harvard Medical School, USA. jwhelan@partners.org
Zeitschrift Fur Rheumatologie
|September 28, 2006
Summary
Rheumatoid arthritis (RA) patients face a doubled risk of lymphoma, particularly those with severe disease. Certain RA treatments may influence lymphoma development, with methotrexate withdrawal showing promise for some EBV-positive tumors.
Area of Science:
- Rheumatology
- Oncology
- Immunology
Context:
- Rheumatoid arthritis (RA) is a systemic autoimmune disease.
- RA patients exhibit increased susceptibility to various organ-specific complications.
- A notable rise in lymphoma incidence among RA patients has been observed.
Purpose:
- To investigate the heightened risk of lymphoma in rheumatoid arthritis patients.
- To explore the relationship between RA severity and lymphoma risk.
- To examine the influence of RA treatments on lymphoma development.
Summary:
- RA patients have a significantly elevated risk of developing lymphoma, approximately double that of the general population.
- The risk is substantially higher in individuals with severe RA, with a notable increase in Hodgkin's disease among men with RA.
- EBV-negative lymphomas are common in RA patients, despite impaired EBV control.
- Methotrexate discontinuation has shown positive responses in some EBV-positive lymphoma cases.
- The role of anti-TNF alpha agents in lymphoma risk remains controversial and requires further investigation.
Impact:
- Highlights the critical need for vigilant lymphoma screening in RA patients.
- Informs clinical decisions regarding RA treatment strategies and their potential oncogenic risks.
- Underscores the complex interplay between autoimmune disease, infection control, and cancer development.
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