Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Growth of Cartilage and Bone Tissue01:27

Growth of Cartilage and Bone Tissue

Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corrigendum to "Mathematical frameworks for left ventricular assist device therapy: Ventricular mechanics, blood rheology, haemodynamics, control, and nonlinear dynamics" [Progr. Biophys. Molec. Biol. 201 (2026) 152-174].

Progress in biophysics and molecular biology·2026
Same author

Mathematical frameworks for left ventricular assist device therapy: Ventricular mechanics, blood rheology, haemodynamics, control, and nonlinear dynamics.

Progress in biophysics and molecular biology·2026
Same author

Computational analysis of thermally reactive MHD thixotropic hybrid nanofluid flow under the influence of natural convection past a stretching surface.

Discover nano·2026
Same author

OracleTrust: A dual-layer provenance-based signature verification scheme for preventing transaction malleability in blockchain.

PloS one·2026
Same author

Intelligent predictive neural network analysis on LTNE impacts on thermophoretic particle deposition in HFE 7100 nanofluid with Co<sub>3</sub>O<sub>4</sub> nanoparticle.

Discover nano·2026
Same author

Regression and statistical analysis of heat transfer enhancement in water/ethylene glycol (40/60) base molybdenum carbide (Mo<sub>2</sub>C) MXene nanofluid using a transient fractional model.

Discover nano·2026

Related Experiment Video

Updated: Jul 19, 2026

Integrated Bone Formation Through In Vivo Endochondral Ossification Using Mesenchymal Stem Cells
06:05

Integrated Bone Formation Through In Vivo Endochondral Ossification Using Mesenchymal Stem Cells

Published on: July 14, 2023

Enhancing tissue integration in cartilage repair procedures.

Charles W Archer1, Samantha Redman, Ilyas Khan

  • 1School of Biosciences and Cardiff Institute of Tissue Engineering and Repair, Cardiff University, Cardiff, UK. Archer@cardiff.ac.uk

Journal of Anatomy
|September 29, 2006
PubMed
Summary

Autologous chondrocyte transplantation shows promise for articular cartilage repair. Improving tissue integration requires further investigation into wound edge biology and chondrocyte responses to trauma for predictable clinical outcomes.

More Related Videos

Establishment and Evaluation of a Sheep Model of Full-thickness Osteochondral Defect
05:23

Establishment and Evaluation of a Sheep Model of Full-thickness Osteochondral Defect

Published on: April 14, 2026

Fabrication of Decellularized Cartilage-derived Matrix Scaffolds
08:02

Fabrication of Decellularized Cartilage-derived Matrix Scaffolds

Published on: January 7, 2019

Related Experiment Videos

Last Updated: Jul 19, 2026

Integrated Bone Formation Through In Vivo Endochondral Ossification Using Mesenchymal Stem Cells
06:05

Integrated Bone Formation Through In Vivo Endochondral Ossification Using Mesenchymal Stem Cells

Published on: July 14, 2023

Establishment and Evaluation of a Sheep Model of Full-thickness Osteochondral Defect
05:23

Establishment and Evaluation of a Sheep Model of Full-thickness Osteochondral Defect

Published on: April 14, 2026

Fabrication of Decellularized Cartilage-derived Matrix Scaffolds
08:02

Fabrication of Decellularized Cartilage-derived Matrix Scaffolds

Published on: January 7, 2019

Area of Science:

  • Orthopedics
  • Regenerative Medicine
  • Biomaterials Science

Background:

  • Autologous chondrocyte transplantation (ACT) is a leading biological repair strategy for articular cartilage defects.
  • Despite good to excellent outcomes, challenges in tissue integration and predictable clinical results persist.
  • Understanding the biological mechanisms of cartilage-cartilage integration is crucial for improving ACT efficacy.

Purpose of the Study:

  • To review literature and present data on the biological challenges of tissue integration in ACT.
  • To investigate the role of the wound lesion edge in cartilage repair.
  • To identify key factors influencing chondrocyte behavior and matrix synthesis for successful integration.

Main Methods:

  • Literature review on cartilage repair and integration.
  • Analysis of experimental data on chondrocyte responses to different trauma types (blunt vs. sharp).
  • Examination of chondrocyte infiltration and proliferation in response to lesion edge characteristics.

Main Results:

  • Variable tissue integration within a single lesion is a significant challenge.
  • Chondrocytes exhibit limited ability to infiltrate existing cartilage or occupy empty lacunae.
  • Blunt trauma induces greater, more widespread chondrocyte proliferation than sharp trauma, with differential cell layer responses.

Conclusions:

  • Successful biological repair via ACT hinges on predictable tissue integration.
  • Controlling trauma-induced cell death and matrix synthesis at the wound edge is critical.
  • Further research into regulating chondrocyte proliferation and infiltration is needed to enhance ACT strategies.