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Related Concept Videos

Protein Import into the Peroxisomes01:27

Protein Import into the Peroxisomes

Cells contain membrane-bound organelles called peroxisomes that oxidize organic molecules by transferring hydrogen atoms to oxygen, producing hydrogen peroxide. Peroxisomes enzymatically convert the released hydrogen peroxide into water and oxygen.
Peroxisomal Protein Import:
Peroxisomes lack the genetic machinery required to code for their own proteins. Hence, most peroxisomal membrane, lumenal and transmembrane proteins are synthesized in the cytoplasm or ER and transported to the peroxisome...
Peroxisomes01:24

Peroxisomes

Peroxisomes are specialized organelles present in fungi, plant, and animal cells. It can vary in number, size, morphology, and activity depending on the type of tissue and the nutritional state of the cell. For example, cells with active lipid metabolism, such as adipocytes, neurons, and hepatocytes, have more peroxisomes than other cells in the body. Besides their primary role in breaking down complex organic molecules, peroxisomes can also synthesize specific macromolecules and participate in...
Peroxisomes01:24

Peroxisomes

Peroxisomes are specialized organelles present in fungi, plant, and animal cells. It can vary in number, size, morphology, and activity depending on the type of tissue and the nutritional state of the cell. For example, cells with active lipid metabolism, such as adipocytes, neurons, and hepatocytes, have more peroxisomes than other cells in the body. Besides their primary role in breaking down complex organic molecules, peroxisomes can also synthesize specific macromolecules and participate in...
Peroxisomes01:30

Peroxisomes

Peroxisomes and mitochondria are two important oxygen-utilizing organelles in eukaryotic cells. Mitochondria carry out cellular respiration—the process that converts energy from food into ATP. Peroxisomes carry out a variety of functions, primarily breaking down different substances, such as fatty acids.The peroxisome is a single membrane-bound cellular organelle that can perform several different functions, including lipid metabolism and chemical detoxification. The enzymes within peroxisomes...
Yeast Signaling01:28

Yeast Signaling

Yeasts are single-celled organisms, but unlike bacteria, they are eukaryotes (cells with a nucleus). Cell signaling in yeast is similar to signaling in other eukaryotic cells. A ligand, such as a protein or a small molecule released from a yeast cell, attaches to a receptor on the cell surface. The binding stimulates second-messenger kinases to activate or inactivate transcription factors that further regulate gene expression. Many of the yeast intracellular signaling cascades have similar...
Bioreactor Controls-III01:22

Bioreactor Controls-III

Strain improvement is a foundational strategy in industrial microbiology aimed at maximizing microbial productivity, particularly because natural isolates typically yield commercially valuable products in very low concentrations. Although optimizing the culture medium and environmental conditions can improve yields, these adjustments are inherently limited by the organism’s genetic potential. As a result, the focus shifts toward genetic modifications to enhance biosynthetic capacity. The...

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Related Experiment Video

Updated: Jul 19, 2026

High-throughput Screening for Protein-based Inheritance in S. cerevisiae
08:12

High-throughput Screening for Protein-based Inheritance in S. cerevisiae

Published on: August 8, 2017

Sharing the wealth: peroxisome inheritance in budding yeast.

Monica Fagarasanu1, Andrei Fagarasanu, Richard A Rachubinski

  • 1Department of Cell Biology, University of Alberta, Medical Sciences Building 5-14, Edmonton, Alberta, Canada T6G 2H7.

Biochimica Et Biophysica Acta
|September 29, 2006
PubMed
Summary

Budding yeast cells ensure peroxisome inheritance through antagonistic proteins Inp1p and Inp2p. Inp1p retains peroxisomes in the mother cell, while Inp2p directs them to the bud, ensuring proper cell division.

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Area of Science:

  • Cell Biology
  • Molecular Biology
  • Genetics

Background:

  • Eukaryotic cell division requires precise partitioning of cellular components.
  • Peroxisome inheritance mechanisms in budding yeast (Saccharomyces cerevisiae) were poorly understood.
  • Organelle segregation ensures daughter cells receive necessary components.

Purpose of the Study:

  • To elucidate the molecular mechanisms regulating peroxisome inheritance during cell division.
  • To identify key proteins involved in peroxisome segregation in Saccharomyces cerevisiae.
  • To understand the antagonistic roles of Inp1p and Inp2p in peroxisome partitioning.

Main Methods:

  • Investigated the functions of peroxisomal proteins Inp1p and Inp2p.
  • Utilized Saccharomyces cerevisiae as a model organism.
  • Examined protein interactions and cellular localization during cell division.

Main Results:

  • Identified Inp1p and Inp2p as critical regulators of peroxisome inheritance.
  • Inp1p anchors peroxisomes to the mother cell cortex via specific interactions.
  • Inp2p acts as a receptor for Myo2p, facilitating bud-directed peroxisome movement.

Conclusions:

  • Inp1p and Inp2p have opposing functions in peroxisome inheritance.
  • Coordinated action of Inp1p and Inp2p ensures equitable peroxisome distribution.
  • These proteins are essential for the faithful segregation of peroxisomes during yeast cell division.