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07:56
Evaluating Regional Pulmonary Deposition using Patient-Specific 3D Printed Lung Models
Published on: November 11, 2020
Particle engineering techniques for inhaled biopharmaceuticals
Sunday A Shoyele1, Simon Cawthorne
13M Health Care Ltd, Morley Street, Loughborough, LE11 1EP, UK. sashoyele@mmm.com
Advanced Drug Delivery Reviews
|September 29, 2006
Summary
Developing biopharmaceuticals for lung delivery requires optimal particle engineering. This review covers advanced techniques like spray drying for effective pulmonary drug delivery, considering scalability and safety.
Area of Science:
- Pharmaceutical Sciences
- Biotechnology
- Materials Science
Background:
- Pulmonary delivery of biopharmaceuticals presents challenges in achieving deep lung deposition while preserving molecular integrity.
- Traditional particle engineering methods are being refined, alongside the development of novel technologies.
Purpose of the Study:
- To review current particle engineering techniques for biopharmaceutical pulmonary delivery.
- To evaluate the suitability of various methods for optimizing deep lung deposition.
Main Methods:
- Review of established and emerging particle engineering technologies.
- Analysis of techniques including milling, spray drying, spray freeze drying, and supercritical fluid technology.
- Consideration of factors such as scalability, cost-effectiveness, and safety.
Main Results:
- Various techniques offer potential for biopharmaceutical particle engineering for pulmonary delivery.
- Some advanced methods show promise but may have limitations regarding harshness or practicality.
- Method selection requires careful consideration of scale-up, cost, and safety.
Conclusions:
- Optimizing particle properties is crucial for effective biopharmaceutical pulmonary delivery.
- Advanced techniques like spray drying are key areas of development.
- Balancing efficacy, practicality, and economic factors is essential for successful pulmonary drug formulation.
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