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Related Concept Videos

Testes: Gross Anatomy01:19

Testes: Gross Anatomy

The testes, also known as testicles, are the male gonads. They are housed within the scrotum, a sac-like structure located beneath the penis. The scrotum's primary role is to regulate the temperature of the testes, which is crucial for sperm production.
Each testis is surrounded by the tunica albuginea, a dense connective tissue layer that provides structural support and protection. This layer is covered by an outer serous membrane called the tunica vaginalis, which helps reduce friction...
Testes: Histology01:27

Testes: Histology

A tough, fibrous membrane, the tunica albuginea, covers the testes, extending inward to form fibrous partitions or septa, dividing them into internal compartments called lobules. Each lobule has 1 to 3 tightly coiled seminiferous tubules where sperm production occurs. These tubules merge into a tubular network at the back of the testis, known as the rete testis. It connects to 15 to 20 efferent ductules, leading to the epididymis.
The spermatogenic cells, responsible for producing sperm, are...

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Morphological changes in the testis induced by diethylcarbamazine.

Karina Lidianne Alcântara Saraiva1, Valdemiro Amaro Junior Silva, Elisângela Santos Ferreira Dias

  • 1Departamento de Biologia Celular e Ultraestrutura, Centro de Pesquisas Aggeu Magalhães (FIOCRUZ), e Laboratório de Imunopatologia Keizo Asami (LIKA), Universidade Federal de Pernambuco, Recife, Brazil.

Reproductive Toxicology (Elmsford, N.Y.)
|September 29, 2006
PubMed
Summary

Diethylcarbamazine (DEC) can cause significant testicular damage in vertebrates, affecting Leydig and Sertoli cells. This antifilarial drug may disrupt microtubule function and hormonal pathways.

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Area of Science:

  • Reproductive Biology
  • Pharmacology
  • Cell Biology

Background:

  • Diethylcarbamazine (DEC) is effective against lymphatic filariasis.
  • DEC's impact on vertebrate reproductive cells is not well understood.

Purpose of the Study:

  • To investigate the effects of DEC on vertebrate testicular cells.
  • To elucidate the cellular mechanisms underlying DEC toxicity.

Main Methods:

  • Testes of DEC-treated animals were analyzed after 12 days.
  • Ultrastructural examination was performed on Leydig cells, Sertoli cells, spermatogonies, and spermatids.

Main Results:

  • DEC treatment led to Leydig cell hypertrophy, steatosis, and nuclear loss.
  • Sertoli cells showed vacuolization, and spermatogonia exhibited apoptosis.
  • Ultrastructural changes included lipid droplets, multivesicular bodies, and abnormal smooth endoplasmic reticulum in Leydig cells.
  • Spermatids displayed vacuolated mitochondria and disorganization of flagellar microtubules.

Conclusions:

  • DEC induces significant testicular toxicity in vertebrates.
  • The drug likely affects microtubule function and may impact hormonal pathways.