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[Hypercoagulability during pregnancy: evidences for a thrombophilic state]
M Maiello1, M Torella, L Caserta
1Dipartimento di Scienze Ginecologiche, Ostetriche e della Riproduzione, Seconda Università degli Studi di Napoli, Napoli.
Minerva Ginecologica
|September 29, 2006
Summary
Pregnancy increases thrombosis risk due to coagulation and fibrinolysis imbalance. Monitoring fibrinolytic markers can help diagnose pregnancy loss risk.
Area of Science:
- Obstetrics and Gynecology
- Hematology
- Thrombosis Research
Context:
- Thrombotic disorders pose significant risks during pregnancy, impacting both mother and fetus.
- Maintaining a balance between coagulation and fibrinolysis is crucial for a healthy pregnancy.
- Hypercoagulable states, like thrombophilia, are of considerable interest during gestation.
Purpose:
- To investigate differences in coagulation and fibrinolysis parameters between pregnant women with and without pregnancy loss and healthy non-pregnant women.
- To assess the role of these parameters in different trimesters of pregnancy.
- To explore the association between recurrent abortions and pregnancy complications.
Summary:
- Pregnant women exhibited decreased free protein S (PS) and fibrinolysis (t-PA/PAI-1) activities, alongside increased Factor VII, Factor VIII, prothrombin fragment 1+2 (F1+2), and D-dimer.
- Women with pregnancy loss showed the lowest t-PA and PAI, and highest FVII and F1+2 values.
- Coagulation/fibrinolysis derangements were more pronounced in women with recurrent abortions, associated with complications like placental abruption and hypertensive disorders.
Impact:
- Findings suggest an excessive hypercoagulable state is linked to pregnancy termination and a moderate risk of thrombosis.
- Monitoring fibrinolytic markers may serve as a valuable diagnostic tool for identifying risks associated with pregnancy termination.
- This research highlights the importance of understanding hemostatic changes during pregnancy for improved maternal and fetal outcomes.
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