Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Regulation of scapula development.

Ruijin Huang1, Bodo Christ, Ketan Patel

  • 1Institute of Anatomy and Cell Biology, Albert-Ludwig-University Freiburg, Albertstr 17, 79104, Freiburg, Germany. ruijin.huang@anat.uni-freiburg.de

Anatomy and Embryology
|September 29, 2006
PubMed
Summary

The scapula develops from somites, with the blade originating from the dermomyotome, a surprising source of cartilage. This process requires specific signals and segment information for scapula formation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Experimental sepsis causes SERCA2 expression in white adipose tissue but not classical browning.

Scientific reports·2026
Same author

Enhanced Stability and Transdermal Delivery of Semaglutide Using an L-Arginine Based Dissolving Microneedle System.

AAPS PharmSciTech·2026
Same author

Leveraging Carnitine-functionalized Lipid Nanocarrier based Targeted Delivery of A1874 PROTAC for Glioblastoma.

Pharmaceutical research·2026
Same author

Targeting Myostatin for Sustainable Meat Production: Insights From Multiple Species.

Animal genetics·2026
Same author

Pediatric Genital Endemic Kaposi Sarcoma with Partial Response to Adapalene.

The American journal of tropical medicine and hygiene·2026
Same author

Effects of Cape Cobra (<i>Naja nivea</i>) Venom and Its Isolated Protein on the Modulation of Platelet Activation.

Toxins·2026

Area of Science:

  • Developmental biology
  • Evolutionary biology
  • Skeletal biology

Background:

  • The scapula, a key bone in the shoulder girdle, exhibits significant evolutionary changes in structure across species.
  • Understanding the developmental mechanisms controlling scapula formation is crucial for insights into skeletal evolution.

Purpose of the Study:

  • To review and elucidate the mechanisms governing scapula development.
  • To investigate the origin and compartmentalization of the scapula during embryonic development.
  • To identify signaling molecules and cellular origins involved in scapula formation.

Main Methods:

  • Review of experimental data including somite extirpation, chick-quail cell marking, and genetic cell labeling.
  • Analysis of gene expression patterns and cellular origins in various species.
  • Examination of the role of signaling pathways (e.g., BMPs) and tissue interactions.

Main Results:

  • The scapula originates from somites, with the blade derived from the dermomyotome and the cranial part from the forelimb field somatopleure.
  • Scapula development represents a novel case of dermomyotomal chondrogenesis, distinct from sclerotomal chondrogenesis.
  • Scapula precursors are located in the hypaxial domain of the dermomyotome, requiring ectoderm-derived signals and BMPs for chondrogenesis.
  • Segment-specific information within the cervicothoracic transition region of somites is essential for scapula formation competence.
  • Neural crest cells may also contribute to scapula development.

Conclusions:

  • Scapula formation involves a unique chondrogenic program initiated in the dermomyotome, regulated by extrinsic signals and intrinsic segment-specific information.
  • The study highlights the plasticity of somitic compartments and the complex interplay of signaling pathways in skeletal development.
  • Further research is needed to fully understand the contribution of neural crest cells and identify all signaling molecules involved.

Related Experiment Videos