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Related Concept Videos

Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
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Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
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Mechanism of Antibiotic Resistance in MRSA

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Inhibitors of Gram-positive Cell Wall Synthesis

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Related Experiment Video

Updated: Jul 19, 2026

Experimental Endocarditis Model of Methicillin Resistant Staphylococcus aureus (MRSA) in Rat
07:46

Experimental Endocarditis Model of Methicillin Resistant Staphylococcus aureus (MRSA) in Rat

Published on: June 4, 2012

The decrease in healthcare-associated methicillin-resistant Staphylococcus aureus infections and savings from

Diler Coskun1, Jale Aytac

  • 1Department of Microbiology, Medical Faculty, Istanbul Science University, Istanbul, Turkey. dilercoskun@yahoo.com

Infection Control and Hospital Epidemiology
|September 29, 2006
PubMed
Summary

Implementing infection control precautions significantly reduced healthcare-associated methicillin-resistant Staphylococcus aureus (MRSA) infections. This also led to a decrease in glycopeptide use and associated expenditures.

Related Experiment Videos

Last Updated: Jul 19, 2026

Experimental Endocarditis Model of Methicillin Resistant Staphylococcus aureus (MRSA) in Rat
07:46

Experimental Endocarditis Model of Methicillin Resistant Staphylococcus aureus (MRSA) in Rat

Published on: June 4, 2012

Area of Science:

  • Infectious Diseases
  • Hospital Epidemiology
  • Antimicrobial Stewardship

Background:

  • Healthcare-associated infections (HAIs) pose a significant challenge.
  • Methicillin-resistant Staphylococcus aureus (MRSA) is a major pathogen contributing to HAIs.
  • Effective infection control is crucial for managing resistant bacteria.

Purpose of the Study:

  • To evaluate the impact of infection control precautions on MRSA and S. aureus infection rates.
  • To assess the effect of these changes on glycopeptide utilization and expenditure.
  • To analyze trends in a Turkish private medical center from 2000-2005.

Main Methods:

  • Retrospective analysis of infection rates before and after intervention.
  • Monitoring of glycopeptide usage and associated costs.
  • Implementation of infection control precautions as the primary intervention.

Main Results:

  • A significant reduction in healthcare-associated MRSA infections was observed.
  • A decrease in overall healthcare-associated S. aureus infections was noted.
  • Expenditures for glycopeptide use also showed a notable decline.

Conclusions:

  • Infection control precautions are effective in reducing MRSA infections.
  • These interventions can lead to decreased antimicrobial use and healthcare costs.
  • Successful implementation of control measures impacts both patient outcomes and resource management.