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Related Experiment Videos

[Constrictive pericarditis and Whipple's disease].

L Freychet1, D Duboc, F Guérin

  • 1Service de cardiologie, hôpital Cochin, Paris.

Archives Des Maladies Du Coeur Et Des Vaisseaux
|October 1, 1990
PubMed
Summary
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Whipple's disease can affect the heart, leading to constrictive pericarditis. This case highlights cardiac involvement and the need for pericardectomy in advanced Whipple's disease.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Pathology

Background:

  • Whipple's disease is a rare systemic bacterial infection typically affecting the small intestine.
  • Cardiac manifestations of Whipple's disease are uncommon but can be severe.

Observation:

  • A 61-year-old patient treated for probable Whipple's disease developed constrictive pericarditis.
  • Intestinal biopsy was negative, but pericardial and myocardial biopsies showed characteristic histological changes.

Findings:

  • Histological examination revealed fibrous pericarditis with mononuclear infiltration and PAS-positive histiocytes in the pericardium.
  • Similar pathological findings were identified in a myocardial biopsy fragment, confirming cardiac localization.

Implications:

Related Experiment Videos

  • This case underscores the importance of considering cardiac involvement in Whipple's disease, even with negative intestinal biopsies.
  • Cardiac Whipple's disease can lead to serious complications like constrictive pericarditis requiring surgical intervention (pericardectomy).