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[Glycosylated hemoglobin and left ventricular diastolic dysfunction in patients with type 2 diabetes mellitus]

Leszek Markuszewski1, Tomasz Grycewicz, Robert Pietruszyński

  • 1Uniwersytet Medyczny w Lodzi, Klinika Kardiologii Interwencyjnej, Kardiodiabetologii i Rehabilitacji Kardiologicznej, I Katedra Kardiologii i Kardiochirurgii kardiolog@skwam.lodz.pl

Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego
|September 30, 2006
PubMed

Insights

Higher glycosylated hemoglobin (HbA1c) levels are linked to increased diastolic dysfunction in diabetes mellitus type 2 patients. This study highlights HbA1c as a key factor influencing heart function in diabetics.

Area of Science:

  • Cardiology
  • Endocrinology
  • Diabetology

Background:

  • Glycosylated hemoglobin (HbA1c) is a critical prognostic indicator for cardiovascular complications in diabetic patients.
  • Elevated HbA1c levels, particularly above 5%, are associated with a 20% increased risk of cardiovascular disease (CD).
  • Diastolic dysfunction is an early indicator of cardiac compromise in diabetes mellitus type 2 (DM 2).

Purpose of the Study:

  • To investigate the relationship between HbA1c levels and left ventricular diastolic dysfunction.
  • To assess diastolic function in DM 2 patients without significant coronary artery disease.

Main Methods:

  • The study included 57 DM 2 patients, categorized by HbA1c levels (< or = 6.1% and >6.1%).
  • Echocardiography was used to evaluate left ventricular diastolic function parameters.
  • Patients with reduced ejection fraction (EF<50%) were excluded.

Main Results:

  • Diastolic dysfunction was significantly more prevalent in patients with HbA1c >6.1% (43%) compared to those with HbA1c <=6.1% (4.5%).
  • In the higher HbA1c group, abnormal relaxation was observed in 38% (early filling) and 5% (isovolumetric).
  • Only one patient (4.5%) in the lower HbA1c group showed abnormal early filling relaxation.

Conclusions:

  • Left ventricular diastolic function in diabetic patients is demonstrably dependent on HbA1c levels.
  • Controlling HbA1c may be crucial for preventing or mitigating diastolic dysfunction in DM 2.
Abstract

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