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Lymphatic innervation.

N G McHale1

  • 1School of Basic Medical Sciences, Queen's University, Belfast, Northern Ireland.

Blood Vessels
|January 1, 1990
PubMed
Summary
This summary is machine-generated.

Nerves in bovine lymphatic vessels release noradrenaline, increasing lymphatic contractions. This response is modulated by alpha-adrenergic receptors and impacts lymph flow in living animals.

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Area of Science:

  • Physiology
  • Neuroscience
  • Lymphatic System Biology

Background:

  • Bovine mesenteric lymphatic vessels possess intrinsic nerves.
  • Sympathetic nervous system activity influences lymphatic function.

Purpose of the Study:

  • To investigate the role of noradrenergic nerves in regulating bovine mesenteric lymphatic vessel contractions.
  • To characterize the adrenergic receptor subtypes involved in lymphatic nerve-mediated responses.

Main Methods:

  • Field stimulation of isolated lymphatic vessels.
  • Measurement of lymphatic contractions and electrical activity.
  • Radioligand ([3H]-noradrenaline) efflux studies.
  • In vivo sympathetic chain stimulation in sheep.

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Main Results:

  • Field stimulation increased lymphatic contraction frequency, mediated by alpha-adrenergic receptors.
  • Noradrenaline release was enhanced by alpha-2 antagonists and reduced by alpha-2 agonists.
  • Electrical activity showed single action potentials preceding contractions, with specific membrane potential changes upon receptor stimulation.
  • Sympathetic stimulation increased lymph flow, blocked by alpha-adrenergic blockers.

Conclusions:

  • Noradrenergic nerves play a significant role in controlling lymphatic vessel contractility and lymph flow.
  • Both postsynaptic alpha- and beta-adrenergic receptors modulate lymphatic electrical and mechanical activity.
  • These findings highlight the importance of neuro-lymphatic interactions in physiological conditions.