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Updated: Jul 19, 2026

Inhibition of Aspergillus flavus Growth and Aflatoxin Production in Transgenic Maize Expressing the α-amylase Inhibitor from Lablab purpureus L.
Published on: February 15, 2019
[A IL-6R antagonist 2520A produced by a fungal species]
Feng-chang Zhu1, Rong Jiang, Yang Zhang
1Institute of Medical Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Aim:
To isolate IL-6R antagonists from the cultured broth of the strain Torulomyces ovatus.
Methods:
Various column chromatographyes were used to separate and purify the compounds with IL-6R antagonist activity. The spectral data and physic-chemical properties were measured for structure identification.
Results:
One compound namely 2520 was isolated from the cultured broth of Torulomyces ovatus.
Conclusion:
2520A is a known compound (ferrichrome). It is first reported about its antagonistic activity of IL-6R and identification of iron atom in its structure.
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