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Synthesis of Protein Bioconjugates via Cysteine-maleimide Chemistry
Published on: July 20, 2016
Total synthesis of the macrocyclic cysteine knot microprotein MCoTI-II
Panumart Thongyoo1, Edward W Tate, Robin J Leatherbarrow
1Biological and Biophysical Chemistry Section, Department of Chemistry, Imperial College London, UK SW7 2AZ.
Chemical Communications (Cambridge, England)
|September 30, 2006
Abstract:
The first total synthesis of MCoTI-II, a cysteine knot microprotein and potent trypsin inhibitor, is described; a synthetic strategy has been developed that combines efficient backbone construction via optimised solid phase peptide synthesis with one-pot 'thia-zip' native chemical ligation and refolding to yield the natural product.
