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Rapid synthesis of diketopiperazine macroarrays via Ugi four-component reactions on planar solid supports

Qi Lin1, Helen E Blackwell

  • 1Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, Wisconsin 53706-1322, USA.

Chemical Communications (Cambridge, England)
|September 30, 2006
PubMed

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The Diels–Alder reaction is an example of a thermal pericyclic reaction between a conjugated diene and an alkene or alkyne, commonly referred to as a dienophile. The reaction involves a concerted movement of six π electrons, four from the diene and two from the dienophile, forming an unsaturated six-membered ring. As a result, these reactions are classified as [4+2] cycloadditions.