Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Extensive mixed vascular malformation clinically imitating multiple sclerosis--case report.

J Rafalowska1, D Dziewulska, A Podlecka

  • 1Department of Experimental and Clinical Neuropathology, Medical Research Centre, Polish Academy of Sciences, Pawinskiego str. 5, 02-106 Warsaw, Poland. ddziewul@amwaw.edu.pl

Clinical Neuropathology
|September 30, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Relationship between chicken proventricular necrosis virus prevalence and transmissible viral proventriculitis in broiler chickens in Poland.

Polish journal of veterinary sciences·2021
Same author

Arginine and tetrahydrobiopterin supplementation in rats with salt-induced blood pressure increase: minor hypotensive effect but improvement of renal haemodynamics.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society·2019
Same author

Altered Cerebrospinal Fluid Concentrations of Hydrophobic and Hydrophilic Compounds in Early Stages of Multiple Sclerosis-Metabolic Profile Analyses.

Journal of molecular neuroscience : MN·2019
Same author

An evaluation of the impact of aloe vera and licorice extracts on the course of experimental pigeon paramyxovirus type 1 infection in pigeons.

Poultry science·2017
Same author

Differentiation of infectious bronchitis virus vaccine strains Ma5 and 4/91 by TaqMan real-time PCR.

Polish journal of veterinary sciences·2017
Same author

Patient-reported quality of life in multiple sclerosis differs between cultures and countries: a cross-sectional Austrian-German-Polish study.

Multiple sclerosis (Houndmills, Basingstoke, England)·2010

This study found diverse vascular malformations in the central nervous system, mimicking multiple sclerosis. These likely resulted from prolonged or intermittent teratogenic factor exposure during fetal development.

Area of Science:

  • Neurology
  • Developmental Biology
  • Pathology

Background:

  • Vascular malformations typically arise from specific teratogenic exposures during embryonic/fetal development.
  • Understanding the origins of complex vascular malformations is crucial for diagnosis and treatment.

Observation:

  • A unique case presented with multiple types of vascular malformations across the central nervous system.
  • These malformations mimicked clinical symptoms of multiple sclerosis.
  • Histological examination revealed cavernous, capillary, and arteriovenous malformations within the meninges and brain/spinal cord white matter.

Findings:

  • Immunocytochemical analysis of endothelial markers (CD31, CD34, von Willebrand factor, Ulex europaeus lectin) was normal.
  • Reduced immunoreactivity to laminin and fibronectin was observed in the vascular basal membrane.

Related Experiment Videos

  • Expression of key growth factors and their receptors (angiopoietin, PDGF, TGF-beta, VEGF receptors) remained undisturbed.

    • Implications:

    • The diverse malformations suggest a persistent or recurring teratogenic influence throughout fetal development.
    • This case highlights the importance of considering vascular etiologies in neurological conditions that mimic demyelinating diseases.
    • Further research into the molecular mechanisms underlying aberrant vascular development is warranted.