Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

T-T cell interactions are mediated by adhesion molecules.

S A Brod1, M Purvee, D Benjamin

  • 1Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115.

European Journal of Immunology
|October 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Search for B(s)(0) → μ+ μ- and B(0) → μ+ μ- decays with CDF II.

Physical review letters·2011
Same author

Search for New T' particles in final states with large jet multiplicities and missing transverse energy in p p collisions at sqrt[s] = 1.96 TeV.

Physical review letters·2011
Same author

Search for new physics in high pT like-sign dilepton events at CDF II.

Physical review letters·2011
Same author

Observation of the Ξ(b)(0) baryon.

Physical review letters·2011
Same author

Measurement of the cross section for prompt isolated diphoton production in pp collisions at square root(s) = 1.96  TeV.

Physical review letters·2011
Same author

Measurement of b-Quark Fragmentation Fractions in pp[over ¯] Collisions at sqrt[s]=1.8 TeV.

Physical review letters·2011

Activated T cells can signal other T cells to proliferate, even without recognizing specific antigens. This T-cell communication relies on cell contact and adhesion molecules, not MHC restriction, suggesting a broad role in inflammatory responses.

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • The precise mechanisms of T cell-to-T cell signaling remain incompletely understood.
  • Investigating how T cells interact and influence each other is crucial for understanding immune responses.

Purpose of the Study:

  • To elucidate the mechanism by which T cells signal and induce proliferation in other T cells.
  • To explore the role of cell adhesion molecules and MHC restriction in T-T cell activation.

Main Methods:

  • Studying the ability of circulating T cells to induce proliferation of autologous T cell clones.
  • Utilizing cross-linking of the CD3/T cell receptor complex to activate T cells.
  • Employing monoclonal antibodies to block specific cell surface molecules.

Main Results:

Related Experiment Videos

  • Activated T cells, with increased adhesion molecules (LFA-1, LFA-3, ICAM-1), induced proliferation of autologous T cell clones.
  • Antigen-activated T cells could induce proliferation in T cell clones lacking antigen specificity.
  • T-T cell activation required cell contact, was MHC-unrestricted, and was inhibited by antibodies against CD2 and LFA-3.

Conclusions:

  • T-cell activation involves cell contact and adhesion molecules, independent of MHC restriction.
  • Increased expression of adhesion molecules like LFA-3 may recruit non-antigen-specific T cells during inflammation via the CD2 pathway.
  • A simplified model suggests T-cell interactions can amplify inflammatory responses, highlighting a novel role for CD2.