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Related Concept Videos

Potentiometry: Membrane Electrodes01:15

Potentiometry: Membrane Electrodes

Membrane electrodes, also known as p-ion electrodes, use membranes that selectively interact with free analyte ions, generating a potential difference across the membrane. The resulting membrane potential, known as the asymmetry potential, is not zero even when analyte concentrations on both sides of the membrane are equal. The membrane's response is typically not selective to a single analyte but proportional to the concentration of all ions in the sample solution capable of interacting at the...
Potentiometry: Types of Electrodes01:19

Potentiometry: Types of Electrodes

Reference electrodes serve as a stable reference point for potentiometric measurements, while indicator and working electrodes react to variations in the composition of a solution.
The Standard Hydrogen Electrode (SHE) is a widely used reference electrode that maintains zero potential across all temperatures. However, its need for a continuous hydrogen gas supply renders it impractical for everyday use.
An alternative to SHE is the Saturated Calomel Electrode (SCE). This electrode features an...
Voltammetric Techniques: Linear-Scan (E vs Time)01:12

Voltammetric Techniques: Linear-Scan (E vs Time)

Polarography is a classical voltammetric technique used to analyze electrochemical reactions. This method applies a linear potential sweep to a dropping mercury electrode (DME), and the resulting current is measured. A dropping mercury electrode is commonly used as the working electrode in polarography. It consists of a capillary tube filled with mercury, where the tiny droplet forms at the tip. This droplet continuously drops from the capillary, creating a new electrode surface for each...
Controlled-Potential Coulometry: Electrolytic Methods01:17

Controlled-Potential Coulometry: Electrolytic Methods

Controlled-potential coulometry, also known as potentiostatic coulometry, employs a three-electrode system in which the working electrode's potential is precisely regulated using a potentiostat. Platinum working electrodes are utilized for positive potentials, while mercury pool electrodes are favored for extremely negative potentials. The platinum counter electrode is separated from the analyte using a membrane or salt bridge to avoid interference in the analysis.
The chosen potential ensures...

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Introduction to Solid Supported Membrane Based Electrophysiology
19:56

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Published on: May 11, 2013

Voltammetric heparin-selective electrode based on thin liquid membrane with conducting polymer-modified solid

Jidong Guo1, Shigeru Amemiya

  • 1Department of Chemistry, University of Pittsburgh, 219 Parkman Avenue, Pittsburgh, Pennsylvania 15260, USA.

Analytical Chemistry
|September 30, 2006
PubMed
Summary

A new solid-supported voltammetric sensor detects heparin, an anticoagulant, with high sensitivity. This novel sensor offers a low detection limit for heparin in saline solutions.

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Multi-analyte Biochip (MAB) Based on All-solid-state Ion-selective Electrodes (ASSISE) for Physiological Research
08:03

Multi-analyte Biochip (MAB) Based on All-solid-state Ion-selective Electrodes (ASSISE) for Physiological Research

Published on: April 18, 2013

Area of Science:

  • Electrochemistry
  • Analytical Chemistry
  • Materials Science

Background:

  • Heparin is a crucial anticoagulant medication.
  • Accurate detection of heparin is vital for patient safety.
  • Existing heparin sensors have limitations in sensitivity or detection methods.

Purpose of the Study:

  • To develop a novel solid-supported voltammetric ion-selective electrode for heparin detection.
  • To investigate the electrochemical behavior of heparin at polarizable membrane/water interfaces.
  • To achieve a lower detection limit for heparin compared to existing sensors.

Main Methods:

  • Fabrication of a solid-supported electrode with a poly(vinyl chloride) (PVC) membrane and a poly(3-octylthiophene) (POT) transducer.
  • Utilizing cyclic voltammetry and convolution techniques to study ion transfer and interfacial processes.
  • Employing stripping voltammetry for sensitive heparin detection.

Main Results:

  • The developed electrode demonstrated reversible charge transport and adequate redox capacity.
  • Interfacial adsorption and desorption of heparin were found to be electrochemically irreversible.
  • A low detection limit of 0.005 unit/mL for heparin was achieved, surpassing current sensors.

Conclusions:

  • The novel solid-supported voltammetric sensor is effective for sensitive heparin detection.
  • The sensor design facilitates ion transfer voltammetry at polarizable interfaces.
  • This technology holds promise for improved anticoagulant monitoring.